Wim Timens Selected Research

Decorin

1/2021	Abnormalities in reparative function of lung-derived mesenchymal stromal cells in emphysema.
1/2020	Link between increased cellular senescence and extracellular matrix changes in COPD.
1/2016	Interleukin-1α drives the dysfunctional cross-talk of the airway epithelium and lung fibroblasts in COPD.
10/2013	Differential effects of fluticasone on extracellular matrix production by airway and parenchymal fibroblasts in severe COPD.
1/2013	Inhaled steroids modulate extracellular matrix composition in bronchial biopsies of COPD patients: a randomized, controlled trial.
8/2012	Differential switching to IgG and IgA in active smoking COPD patients and healthy controls.
12/2008	Smad gene expression in pulmonary fibroblasts: indications for defective ECM repair in COPD.
3/2005	Different modulation of decorin production by lung fibroblasts from patients with mild and severe emphysema.

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Wim Timens Research Topics

Disease

99	Chronic Obstructive Pulmonary Disease (COPD) 01/2022 - 10/2003
33	Inflammation (Inflammations) 01/2022 - 08/2002
33	Asthma (Bronchial Asthma) 01/2022 - 06/2005
19	Neoplasms (Cancer) 03/2022 - 11/2002
18	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2022 - 11/2002
16	Emphysema 01/2021 - 07/2003
12	Lung Neoplasms (Lung Cancer) 11/2020 - 05/2006
8	Lung Diseases (Lung Disease) 01/2020 - 08/2004
6	Airway Remodeling 01/2022 - 01/2013
5	COVID-19 06/2021 - 01/2020
4	Adenocarcinoma of Lung 11/2021 - 12/2010
4	Respiratory Hypersensitivity 01/2021 - 06/2004
3	Adenocarcinoma 02/2022 - 01/2011
3	Pneumonia (Pneumonitis) 01/2016 - 01/2008
3	Airway Obstruction (Choking) 10/2015 - 07/2006
2	Disease Progression 01/2020 - 01/2008
2	Chronic Bronchitis 01/2020 - 11/2005
2	Vascular Remodeling 01/2016 - 03/2015
2	Fibrosis (Cirrhosis) 03/2015 - 07/2006
2	Obstructive Lung Diseases (Obstructive Lung Disease) 01/2014 - 11/2012
2	Chronic Disease (Chronic Diseases) 01/2013 - 01/2011
2	Breast Neoplasms (Breast Cancer) 01/2007 - 06/2005
1	Papillary Carcinoma 02/2022

Drug/Important Bio-Agent (IBA)

29	SmokeIBA 01/2022 - 07/2003
23	Proteins (Proteins, Gene)FDA Link 01/2022 - 11/2002
22	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2022 - 01/2007
13	CytokinesIBA 10/2020 - 08/2002
12	Messenger RNA (mRNA)IBA 01/2021 - 03/2004
10	MicroRNAs (MicroRNA)IBA 01/2022 - 01/2013
9	Biomarkers (Surrogate Marker)IBA 01/2022 - 05/2013
8	DecorinIBA 01/2021 - 03/2005
8	CollagenIBA 01/2020 - 01/2009
7	Biological ProductsIBA 01/2020 - 01/2014
7	GoldIBA 01/2020 - 12/2008
7	SteroidsIBA 01/2019 - 10/2009
7	Fluticasone (Cutivate)FDA LinkGeneric 01/2019 - 10/2009
7	multidrug resistance-associated protein 1IBA 12/2012 - 06/2005
5	LigandsIBA 01/2021 - 08/2003
5	InterleukinsIBA 01/2020 - 07/2005
4	RNA (Ribonucleic Acid)IBA 03/2022 - 01/2020
4	B7-H1 AntigenIBA 01/2022 - 10/2019
4	Bronchodilator Agents (Bronchodilators)IBA 01/2021 - 03/2011
4	OvalbuminIBA 01/2016 - 08/2002
4	Interleukin-8 (Interleukin 8)IBA 01/2016 - 04/2005
4	Adenosine Monophosphate (AMP)IBA 01/2015 - 06/2008
3	DNA (Deoxyribonucleic Acid)IBA 03/2022 - 01/2017
3	ElastinIBA 02/2022 - 11/2009
3	Anaplastic Lymphoma KinaseIBA 01/2022 - 12/2010
3	Interleukin-6 (Interleukin 6)IBA 01/2021 - 07/2005
3	Angiotensin-Converting Enzyme 2IBA 12/2020 - 01/2020
3	Transforming Growth Factor beta (TGF-beta)IBA 11/2020 - 12/2008
3	GasesIBA 01/2020 - 01/2009
3	Proteoglycans (Proteoglycan)IBA 01/2018 - 12/2008
3	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 09/2013 - 07/2006
3	AntigensIBA 08/2012 - 04/2006
2	Immune Checkpoint InhibitorsIBA 11/2021 - 11/2021
2	Circulating Tumor DNAIBA 11/2021 - 11/2021
2	Interleukin-10 (Interleukin 10)IBA 01/2021 - 12/2011
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2021 - 01/2011
2	Formaldehyde (Formol)FDA Link 01/2021 - 10/2020
2	ParaquatIBA 01/2021 - 01/2020
2	Cholinergic Agents (Cholinergics)IBA 01/2021 - 01/2020
2	Serine Proteases (Serine Protease)IBA 12/2020 - 11/2020
2	Budesonide (Pulmicort)FDA LinkGeneric 10/2020 - 01/2013
2	Interleukin-1 (Interleukin 1)IBA 01/2020 - 01/2017
2	Phosphodiesterase 4 InhibitorsIBA 01/2020 - 10/2003
2	Peptides (Polypeptides)IBA 01/2020 - 09/2013
2	AllergensIBA 12/2019 - 07/2006
2	Laminin (Merosin)IBA 12/2019 - 01/2009
2	ErbB Receptors (EGF Receptor)IBA 03/2019 - 12/2010
2	Chemokine ReceptorsIBA 03/2019 - 03/2004
2	Interleukin-17 (Interleukin 17)IBA 01/2019 - 07/2005
2	CrizotinibIBA 01/2018 - 01/2016
2	Pharmaceutical PreparationsIBA 01/2018 - 10/2015
2	Fluticasone-Salmeterol Drug Combination (Advair)FDA Link 01/2017 - 11/2012
2	ChemokinesIBA 01/2016 - 07/2007
2	Phosphotransferases (Kinase)IBA 11/2015 - 06/2011
2	Nicotine FDA Link 10/2015 - 01/2012
2	CateninsIBA 01/2015 - 01/2011
2	erythromycin propionate-N-acetylcysteinateIBA 11/2014 - 01/2012
2	Transforming Growth Factors (Transforming Growth Factor)IBA 10/2013 - 12/2011
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2013 - 12/2009
2	AutoantibodiesIBA 08/2012 - 12/2010
2	Interleukin-13IBA 12/2011 - 06/2008
2	Fibronectins (Fibronectin)IBA 01/2011 - 03/2005
2	AntibodiesIBA 12/2010 - 04/2006
2	Purinergic P1 Receptors (Adenosine Receptor)IBA 03/2009 - 06/2008
2	Adenosine (Adenocard)FDA LinkGeneric 03/2009 - 06/2008
2	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 03/2009 - 03/2004
2	Interleukin-4 (Interleukin 4)IBA 06/2008 - 01/2004
2	Interferon-gamma (Interferon, gamma)IBA 03/2005 - 01/2004
1	Tobacco Smoke Pollution (Passive Smoking)IBA 01/2022
1	Indicators and Reagents (Reagents)IBA 01/2022
1	Protein-Lysine 6-Oxidase (Lysyl Oxidase)IBA 01/2022
1	AsbestosIBA 01/2022
1	Blood Proteins (Serum Proteins)IBA 06/2021

Therapy/Procedure

26	Therapeutics 01/2021 - 10/2003
5	Immunotherapy 01/2022 - 05/2016
3	Lung Transplantation 04/2009 - 08/2004
2	Drug Therapy (Chemotherapy) 12/2019 - 04/2015